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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LMNA All Species: 28.79
Human Site: S525 Identified Species: 57.58
UniProt: P02545 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P02545 NP_005563.1 664 74139 S525 N T W G C G N S L R T A L I N
Chimpanzee Pan troglodytes NP_001092024 664 74135 S525 N T W G C G N S L R T A L I N
Rhesus Macaque Macaca mulatta XP_001113604 726 80498 S587 N T W G C G N S L R T A L I N
Dog Lupus familis XP_864434 665 74207 S526 N T W G C G N S L R T A L I N
Cat Felis silvestris
Mouse Mus musculus P48678 665 74219 S525 N T W G C G S S L R T A L I N
Rat Rattus norvegicus P48679 665 74305 S525 N T W G C G T S L R T A L I N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516432 873 92759 S596 R G D G R E R S A S V A P W S
Chicken Gallus gallus P13648 657 73146 S520 V V W K A Q S S W G S G D S L
Frog Xenopus laevis P11048 665 74901 S522 S S W G T G D S I R T A L L T
Zebra Danio Brachydanio rerio NP_694503 659 73714 A518 Q T V T I W A A G A G G T H S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P08928 622 71282 N489 G K F V R L F N K G S E E V A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q21443 566 64066 L433 E D Q D I D Y L N R R S K L N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 90.5 98 N.A. 96.5 97.1 N.A. 47.4 78.6 73.3 66.7 N.A. 35 N.A. 27.5 N.A.
Protein Similarity: 100 99.8 90.9 99.2 N.A. 98.9 98.9 N.A. 54.9 86.7 86.1 81.6 N.A. 57.9 N.A. 43.8 N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 20 13.3 53.3 6.6 N.A. 0 N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. 26.6 26.6 86.6 20 N.A. 26.6 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 9 9 9 9 0 67 0 0 9 % A
% Cys: 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 9 9 0 9 9 0 0 0 0 0 9 0 0 % D
% Glu: 9 0 0 0 0 9 0 0 0 0 0 9 9 0 0 % E
% Phe: 0 0 9 0 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 9 9 0 67 0 59 0 0 9 17 9 17 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 0 0 0 17 0 0 0 9 0 0 0 0 50 0 % I
% Lys: 0 9 0 9 0 0 0 0 9 0 0 0 9 0 0 % K
% Leu: 0 0 0 0 0 9 0 9 50 0 0 0 59 17 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 50 0 0 0 0 0 34 9 9 0 0 0 0 0 59 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % P
% Gln: 9 0 9 0 0 9 0 0 0 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 17 0 9 0 0 67 9 0 0 0 0 % R
% Ser: 9 9 0 0 0 0 17 75 0 9 17 9 0 9 17 % S
% Thr: 0 59 0 9 9 0 9 0 0 0 59 0 9 0 9 % T
% Val: 9 9 9 9 0 0 0 0 0 0 9 0 0 9 0 % V
% Trp: 0 0 67 0 0 9 0 0 9 0 0 0 0 9 0 % W
% Tyr: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _